Players are back in training, new signings are settling in and clubs begin their pre-season fixtures this week.
The new campaign begins on Friday 13 August, as newcomers Brentford host Arsenal.
In other standout games in the opening round of matches, Manchester United take on rivals Leeds on Saturday, promoted Norwich play Liverpool on the same day, while champions Manchester City are at Tottenham on Sunday.
The final round of matches takes place on Sunday 22 May 2022, with all fixtures kicking off simultaneously.
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When does the season start?
Are fans allowed in to stadiums?
Supporters were allowed into grounds for their team’s final game of last season, with up to 10,000 fans in attendance or a quarter of the stadium’s capacity.
The UK government announced that restrictions in England will end on 19 July with the Premier League saying they hope of having “full stadiums for the start of the 2021-22 season”.
Prime Minister Boris Johnson said they will “remove all legal limits” on people meeting indoors and outdoors including at sports events.